Abstract

Case Report

Linear IgA bullous dermatosis in a child successfully responding to oral antibiotics

G Senhaji*, H Bay Bay, O El Jouari, A Lamouaffaq, Z Douhi, S Elloudi, FZ Mernissi and R Dassouli

Published: 06 December, 2018 | Volume 2 - Issue 1 | Pages: 008-011

Linear IgA bullous dermatosis (LABD) is a rare, chronic, autoimmune bullous dermatosis affecting young children and adults. The exact pathogenesis of this disease is still unknown, although both humoral and cellular immune response are involved. Clinically, it may show heterogeneous skin manifestations. However, it is characterized histologically by linear immunoglobulin A (IgA) deposits over the basal membrane, causing subepidermal blisters. Studies on LABD are relatively sparse and most of the publications are small series or single case reports. Several treatments are reported in literature, however, they should be used with care due to the risk of side effects. We report a case of linear IgA dermatosis with generalized lesions in a 7 year old child, with good outcome under dermocorticoids and antibiotics.

Read Full Article HTML DOI: 10.29328/journal.adr.1001005 Cite this Article Read Full Article PDF

Keywords:

Linear IgA bullous dermatosis; Autoimmune bullous dermatosis; Subepidermal blisters; Antibiotics

References

  1. Lings K, Bygum A. Linear IgA Bullous Dermatosis: A Retrospective Study of 23 Patients in Denmark. Acta Derm Venereol. 2015; 95: 466-471. Ref.: https://goo.gl/nN4mZG
  2. De las Heras MN. Linear IgA bullous dermatosis of childhood: good response to antibiotic treatment. Clin Exp Dermatol. 2014; 39: 395-397. Ref.: https://goo.gl/zN6fci
  3. Machado TYS, Enokihara MMSS, Iida TM, Porro AM. Adult linear IgA bullous dermatosis: report of three cases. An Bras Dermatol. 2018; 93: 435-437. Ref.: https://goo.gl/7uuDa1
  4. Chaudhari S, Mobini N. Linear IgA Bullous Dermatosis A Rare Clinicopathologic Entity with an Unusual Presentation. J Clin Aesthet Dermatol. 2015; 8: 43-46. Ref.: https://goo.gl/9Zf9KK
  5. Gouveia AI, Teixeira A, Freitas JP, Soares-de-Almeida L, Filipe P, et al. Linear Immunoglobulin A Bullous Dermatosis. J Pediatr. 2016; 170: 338-338. Ref.: https://goo.gl/m2E7Gh
  6. Fernandes KAP, Galvis KH, Gomes ACMS, Nogueira OM, Felix PAO, et al. Linear IgA and IgG bullous dermatosis. An Bras Dermatol. 2016; 91 (5 Supl 1): S32-34. Ref.: https://goo.gl/kuyAF8
  7. Chanal J, Ingen-Housz-Oro S, Ortonne N, Duong TA, Thomas M, et al. Linear IgA bullous dermatosis: comparison between the drug-induced and spontaneous forms. Br J Dermatol. 2013; 169: 1041-1048. Ref.: https://goo.gl/oQY68Q
  8. Ferreira H, Vilarinho C. Linear IgA dermatosis: An atypical manifestation of a rare disease. Pediatr Neonatol. 2018; 59: 324-325. Ref.: https://goo.gl/Fg2GxP

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