Abstract

Case Report

Daub, Discolouration, Pigmentation-Solar Lentigo

Anubha Bajaj*

Published: 07 August, 2019 | Volume 3 - Issue 1 | Pages: 001-006

Solar lentigo is defined as an alteration in cutaneous pigment deposition on account of exposure to ultraviolet radiation. Solar lentigo is a benign, pigmented lesion with a characteristic increment in the quantification of pigmented keratinocytes. It can manifest as a dark brown spot on the skin.

The benign, pigmented spot or solar lentigo or multiple solar lentigines are preponderantly delineated in the sun exposed skin in a majority (> 90%) of Caucasians above 60 years of age although younger individuals and Asians can be implicated.

Solar lentigines are induced by repetitive exposure to ultraviolet light with constituent mutagenic potential. Ultraviolet radiation can induce a localized proliferation of melanocytes with a subsequent accumulation of melanin within the keratinocytes.

Individuals who are genetic carriers of one or two melanocortin-1- receptor (MC1R) gene or cogent variants demonstrate a 1.5 to twice the probability of developing solar lentigines [1,2].

Read Full Article HTML DOI: 10.29328/journal.adr.1001006 Cite this Article Read Full Article PDF

References

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  2. Scarcella G, Dethlefsen MW, Nielsen MCE. Treatment of solar lentigines using a combination of picosecond laser and biphotonic treatment. Clin Case Rep. 2018: 6; 1868-1970. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30214780
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  10. Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, et al. A polymorphism in IRF4 affects human pigmentation through tyrosine dependent MITF/TFAP2A pathway. Cell. 2013; 155: 1022-1033. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24267888
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