Abstract

Review Article

The coral crunch: Amyloidoma

Anubha Bajaj*

Published: 20 January, 2021 | Volume 5 - Issue 1 | Pages: 001-005

Amyloidoma is an exceptional, progressive disorder demonstrating a characteristic accumulation of significant quantities of amyloid within soft tissues. Amyloidoma is additionally nomenclated as tumoural amyloidosis, nodular amyloid or localized amyloidosis. Furthermore, insulin-derived amyloidoma is referred to as insulin ball. Amyloid is a protein polymer configured of identical monomeric protein units wherein pathological variety is articulated from misfolded proteins. In excess > of twenty three subtypes of proteins can configure amyloid fibres in vivo. Extra-cellular or intra-cellular deposition of amyloid can modify normal organ function [1].

Amyloidosis is categorized into systemic and localized subtypes. Localized amyloidosis displays a localized mass effect and demonstrates a superior prognosis. Insulin-derived amyloidosis was initially documented by Storkel, et al. in 1983 who recognized accumulated insulin- amyloid fibrils in diabetic individuals subjected to continuous infusion of porcine insulin over a period of 5 weeks or more [1,2]. Amyloid nodules may be associated with systemic amyloidosis.

Read Full Article HTML DOI: 10.29328/journal.adr.1001013 Cite this Article Read Full Article PDF

Keywords:

Antisecretory function; Cross-reactivity; Delayed reaction; Famotidine; Hypersensitivity; Maculopapular exanthema; Patch test; Ranitidine

References

  1. Musat G, Evsei A, Calina D, Docea AO, Doukas SG, et al. Rare amyloidoma of the tongue base – a case report and review of the literature. Mol Clin Oncol. 2020; 12: 258-262. PubMed: https://pubmed.ncbi.nlm.nih.gov/32064103/
  2. Storkel S, Schneider HM, Müntefering H, Kashiwagi S. Iatrogenic, insulin-dependent, local amyloidosis. Lab Invest. 1983; 48; 108-111. PubMed: https://pubmed.ncbi.nlm.nih.gov/6337294/
  3. Gertz MA. Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment. Am J Hematol. 2020; 95: 848-860. PubMed: https://pubmed.ncbi.nlm.nih.gov/32267020/
  4. Samlaska C, Reber S. Murry T. Insulin-derived amyloidosis – the insulin ball, amyloidoma. JAAD Case Rep. 2020; 6; 351-353. PubMed: https://pubmed.ncbi.nlm.nih.gov/32258319/
  5. Geller HI, Singh A, Mirto TM, Padera R, Mitchell R, et al. Prevalence of monoclonal gammopathy in wild-type transthyretin amyloidosis. Mayo Clin Proc. 2017; 92: 1800-1805. PubMed: https://pubmed.ncbi.nlm.nih.gov/29202938/
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  7. Westermark P. Localized AL amyloidosis- a suicidal neoplasm? Ups J Med Sci. 2012; 117: 244-250. PubMed: https://pubmed.ncbi.nlm.nih.gov/22335280/
  8. O’Reilly A, D’Souza A, Lust J, Price D. Localized tongue amyloidosis – a single institutional case series. Otolaryngol Head Neck Surg. 2013: 149: 240-244. PubMed: https://pubmed.ncbi.nlm.nih.gov/23715681/
  9. Hazenberg BP. Amyloidosis-a clinical review. Rheum Dis Clin North Am. 2013; 39: 323-345. PubMed: https://pubmed.ncbi.nlm.nih.gov/23597967/
  10. Balwani MR, Kute VB, Shah PR, Wakhare P, Trivedi HL. Secondary renal amyloidosis in a patient of pulmonary tuberculosis and common variable deficiency. J Nephropharmacol. 2015; 4: 69-71. PubMed: https://pubmed.ncbi.nlm.nih.gov/28197481/
  11. Charlot M, Seldin DC, O'hara C, Skinner M, Sanchorawala V. Localized amyloidosis of the breast – a case series. Amyloid. 2011: 18; 72-75. PubMed: https://pubmed.ncbi.nlm.nih.gov/21501022/
  12. Kubota K, Ito R, Furudate K, Kon T, Nakagawa H, et al. Localized AL amyloidosis of the tongue-a case report and literature review. J Oral Maxillofac Surg Med Pathol. 2017; 29: 142-145

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